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Probiotics 101: The Strain Matters

By Denika Petzer — Development and Quality Control Technologist at FoodGrown

in Lifestyle
Reading Time: 5 min
Warrior yoga exercise. Young fitness woman is on the field outdoors.

Warrior yoga exercise. Young fitness woman is on the field outdoors.

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The word “probiotic” is everywhere.

You see it on supplement bottles, yoghurt tubs and fermented drinks. It has become almost synonymous with good gut health.

But there is an important detail that is easy to miss.

Probiotics are not one ingredient with one purpose.

Different probiotic micro-organisms can perform different functions. Their effects can also depend on the strain, dose and health concern being addressed.

That means choosing a probiotic supplement is about more than finding the biggest number on the front of the bottle.

Woman, nature fitness or hands on stomach in diet wellness, body healthcare or abs muscle growth in workout training or sunrise exercise. Zoom, sports athlete or person, belly digestion or strong gut

What exactly are probiotics?

Probiotics are live micro-organisms, usually bacteria or yeasts, that may provide a health benefit when consumed in adequate amounts.

The human body already hosts a large and diverse community of micro-organisms. Many of them live in the digestive tract.

Together, these micro-organisms form part of the gut microbiome.

The microbiome interacts with the food we eat, the intestinal lining and the immune system. Some micro-organisms help break down compounds in food, produce useful substances and limit the growth of less desirable microbes.

A probiotic supplement introduces selected live micro-organisms into this environment.

Its purpose is not to sterilise the gut or completely repopulate it. Instead, a suitable strain may support a particular function or help the microbial community recover after it has been affected by factors such as illness, medication, dietary changes, stress or travel.

That distinction matters.

The name on the label matters too

Probiotic names can look complicated. However, each part can provide useful information.

A label might identify a micro-organism by its genus, species and strain, such as Lacticaseibacillus rhamnosus GG.

The letters or numbers at the end identify the strain.

Think of it like dog breeds.

A German Shepherd and a Beagle are both dogs. Yet their characteristics and capabilities can differ.

Probiotic strains can work in a similar way.

Two strains from the same species should not automatically be expected to produce identical results.

This is why a label that simply says “Lactobacillus” or “Bifidobacterium” may not tell the consumer enough. These are broad groups containing numerous species and strains.

A well-labelled supplement should identify its micro-organisms in enough detail for their documented uses to be checked.

Most importantly, evidence for one probiotic strain cannot simply be applied to every other probiotic.

A useful question to ask is:

“Does this strain, at this dose, have evidence for the reason I am considering it?”

What can probiotics help with?

Probiotic research is generally linked to specific digestive concerns rather than broad promises of better health.

Certain strains may help reduce the risk or duration of some forms of diarrhoea, including diarrhoea associated with antibiotic use.

Other strains have been studied for constipation, lactose digestion and symptoms such as abdominal discomfort, bloating and irregular bowel movements.

Probiotics are also widely discussed in relation to irritable bowel syndrome (IBS).

However, research results remain mixed. One reason is that studies can involve different strains, combinations and doses.

A product that helps one group of people, or one particular IBS symptom, may not have the same effect in another setting.

The gut, immune system and brain

The gut has close links with both the immune and nervous systems.

A large proportion of the body’s immune activity is associated with the gastrointestinal tract. There, immune cells must distinguish between harmless substances and possible threats.

Certain probiotic strains may support the way the gut and immune system work together.

Again, however, the potential benefit depends on the specific strain, rather than probiotics as a general category.

Researchers are also studying the gut-brain connection — the two-way communication between the digestive system and the brain.

The research is still developing.

For that reason, probiotics should not be presented as treatments for anxiety, depression or other mental health conditions unless a healthcare professional recommends their use as part of an appropriate care plan.

So, how do you choose a probiotic?

Start with one simple question:

Why do you want to take it?

Different probiotic species and strains have been studied for different digestive needs. Therefore, a broad “gut health” claim does not necessarily tell you whether a particular product is suitable for your concern.

Then look beyond the headline number.

You may see a colony-forming unit (CFU) count on the label. This indicates the approximate number of live micro-organisms in each dose.

But there is no single ideal CFU count for every digestive concern.

What matters is whether the product contains the particular strains, in an amount shown to be useful for the reason you are taking it.

Also check the:

  • Dosage
  • Storage instructions
  • Expiry date
  • Specific probiotic strains listed on the label

Probiotics are living micro-organisms. Heat, moisture and incorrect storage can affect them.

If you are unsure how to interpret a label or choose a formulation, a pharmacist or healthcare professional can help.

Are fermented foods probiotics?

Fermented foods can introduce live micro-organisms into the diet.

Examples include yoghurt with live cultures, kefir, kimchi and unpasteurised sauerkraut.

They can also contribute nutrients and variety to an eating pattern that includes vegetables, fruit, legumes, whole grains, nuts and seeds.

But there is an important distinction:

Fermented does not always mean probiotic.

Processing or pasteurisation may remove live microbes. In addition, the strains or quantities found in a particular food may not have been tested for a specific health benefit.

Fermented foods can still be valuable.

However, they are not necessarily interchangeable with a probiotic supplement selected for a defined purpose.

What are prebiotics?

Then there are prebiotics.

Prebiotics are compounds, often specialised forms of dietary fibre, that are used by beneficial micro-organisms in the gut.

They occur naturally in foods such as:

  • Onions
  • Garlic
  • Leeks
  • Oats
  • Legumes
  • Bananas
  • Certain vegetables

The difference is straightforward.

Probiotics introduce live micro-organisms. Prebiotics help nourish parts of the microbial community already present.

Some supplements combine both and are known as synbiotics.

Once again, the label matters. Ingredients and doses should be clearly identified rather than judged simply by the category name.

Can probiotics cause side effects?

Healthy adults generally tolerate probiotics well.

However, mild bloating, gas or changes in bowel habits can occur when starting a new supplement. These effects often settle as the digestive system adjusts.

Persistent or severe symptoms warrant medical advice.

Certain people should seek professional guidance before taking probiotics.

This includes people who are critically ill, have severely weakened immune systems, use certain medical devices or have serious underlying conditions.

Parents should also consult a healthcare professional before giving probiotic supplements to premature or medically vulnerable infants.

The label is only the beginning

Choosing a probiotic should start with a clear reason.

From there, consumers should consider the strain, dose, formulation and supporting evidence.

The biggest number on a bottle does not automatically make a product the right choice.

Neither does the word “probiotic”.

As probiotic products become increasingly common, understanding what is actually inside the bottle becomes increasingly important.

Because when it comes to probiotics, the category name is only the beginning of the conversation.

This article is intended for general informational purposes and does not constitute medical advice. Consult a healthcare professional before making changes to your supplement routine.

About the author

Denika Petzer holds a BSc in Consumer Science with honours and serves as Research & Development and Quality Control Technologist at FoodGrown and NPL.

She specialises in new product development for FMCG and pharmaceutical brands across the NPL group, including complementary and alternative medicines, sports supplements and vitamins.

Her responsibilities include product compliance verification, market release authorisation and collaboration with the Creative Director on packaging development.

Denika ensures products meet food safety and pharmaceutical regulatory standards (SAHPRA) and that products reaching consumers meet quality requirements.

Her expertise in quality control and product development informs her work in advancing consumer health and nutrition.

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